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About William J. Walker, Pharm.D.
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You are here: Experts > Health/Fitness > Pharmacology > Pharmacy > What is the drug Ticlid used...
Expert: William J. Walker, Pharm.D.
Date: 9/20/2004
Subject: What is the drug Ticlid used...
Question
What is the drug Ticlid used for and what are the known side effects?
Answer
Ticlodipine is a platelet aggregation inhibitor that functions similarly to low dose aspirin. It is used in a variety of situations where aspirin could also be employed. For the prevention of stroke, cerebrovascular accidents, trans-ischemic attacks, and various thrombotic disorders. It can be utilized to prevent clotting of stents and other angiographic procedures. It can be helpful in patients who cannot take aspirin as a substitute but it can also be used together with aspirin in angioplasty to augment the effects. They do work by distinctly different mechanisms of action.
Adverse effects are actually rather common. Although more than half of all patients will experience side effects those that occur tend to be mild and non-threatening. Patients do experience diarrhea and rash primarily. Other GI effects are also common. Including a GI irritation similar to aspirin. Bleeding can also occur, usually in individuals with other existing risk factors. A more serious potential problem is that of neutropenia. Other hematological problems can also occur but the most threatening is this lowering of white cells. Fever is the best indicator of the emergence of this problem. Also noted are thrombocytopenia (lowering of platelets) and aplastic anemia (reducing all blood cells). GI complaints are common, diarrhea being most frequent at 40%. Nausea, vomiting, and flatulence also occur. Rash is a problem in about 5%. Mostly transient and self resolving. Typically the rash is pruritic (itchy) but can also be papular. More serious rashes are also possible including Stevens-Johnson syndrome and lupus like conditions. Liver toxicities are possible as are renal toxicities. Headache, dizziness, and muscular problems have also occured in some. It has even been linked to raising serum cholesterol, which is not a positive development for many of the patients who would be candidates for this agent. Amongst the available agents to choose from within this therapeutic category ticlodipine is perhaps the least favorable. Safer choices include both Plavix and Pletal.
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