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Rabbits/Chronic use of cisispride


I have two elderly, bonded rabbits who both had to have their incisors removed due to malocclusion. I don't know whether this has increased their propensity for stasis but in the last few years, both of them have regular bouts of stasis. It's odd because their molars are pretty good because they are excellent hay eaters. Because they are elderly (both probably at least 10 years), as soon as there are sypmtoms, I hit them hard and fast with cisipride, ovol, metacam, and sometimes sub q fluids as well as a vet visit if it isn't Sunday night on a long weekend. :)
Both of them were having a slowdown at the same time, so I have been giving them cisipride once a day for about 2 weeks now. Do you know what the implications are for keeping them on cisipride daily? One of them also gets Metacam once a day for severe spinal arthritis  as well.
Thank you for your help. Wish I could have gone to St. Louis and met you!

Hi, Mary!

Yes, it's a shame you couldn't make it to St. Louis.  It was a fantastic conference, and the St. Louis people are incredible.  Their shelter made me want to curl up into a little fetal ball and rock back and forth with the knowledge that I'll never be able to do anything like that!  :(

As far as your bunnies and the cisapride are concerned...there are apparently no long-term health problems associated with it, especially if it's just on again, off again.  I know of a Rhesus monkey who was on it every day for his entire life, just to keep him alive.  He suffered no ill effects from the drug, and in fact had a tragic end--he was euthanized when cisapride was briefly taken off the market because he could not survive without the drug.  SO SAD.

If you're worried, why not try the Enema Solution?  Christie Taylor, Brent Dressler and I made an instructional video you can watch, and then perhaps get some coaching from your vet before you try it:

The article has a link to the video at the bottom.

Hope it will help!



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Dana Krempels, Ph.D.


I've lived with companion rabbits for more than 35 years, and consider them members of my family. I can answer any questions about the biology and health of rabbits, from the commonplace to the unusual. But please note:

RULE #1:

Find a rabbit vet at for immediate help, and don't risk your bunny's life by spending time asking questions online! If you can't get in touch with your vet, read these Emergency Sick Bunny Instructions.

If you have found a wild baby rabbit, please read these EMERGENCY INSTRUCTIONS FOR WILD BABY RABBITS and then use this link to FIND A LOCAL WILDLIFE REHABILITATOR who can give you the right advice.

RULE #2:
Help me help you! Please make your subject line informative if you have an urgent question. then LET ME KNOW IN THE SUBJECT LINE so I can give your question highest priority over non-urgent questions. If you don't do this, then I can't guarantee timely assistance!

For all the best, most accurate rabbit health, care and behavior information, visit The House Rabbit Society.


I have been rescuing and rehabilitating domestic and wild rabbits for about 30 years. I have written articles for many rabbit rescue publications, as well as for the veterinary journal, Exotic DVM. I own EtherBun, the internet's largest listserve dedicated to health, care, and behavior of domestic rabbits.

Houserabbit Adoption, Rescue, and Education, Inc. (H.A.R.E., Inc.) president National House Rabbit Society (Board member)

Exotic DVM
Warren Peace (Journal of the House Rabbit Society of Miami)
Various newsletters of the House Rabbit Society, nationwide

Ph.D - Biology
B.S. - Biology
B.A. - English

Awards and Honors
Lightspan Academic Excellence Award for web site on rabbit health and biology

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