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Rabbits/Living with snuffles for three years thanks to your cocktail


Hi! My three year old doe has had snuffles since she was a baby, none of the vet's advise worked until I tried a cocktail you recommended to someone else in one of your answers. It was amikasin, amoxicillin and acetilsisteine in a nebulizer twice a day for a month. I did it religiously and she was good for two years. Now she has it again, this time she has the mucus I the nose, little sneezing but what worries me the most is her teary eye. I guess the mucus is blocking her eye ducts. I have started nebulizing cocktail again for 5 days now. Some days she has appeared to be better, others still very wet around the eye. I know it has only been 5 days but I worry: do you think appropriate to give her oral baytil in addition to the cocktail to help put out this outbreak? Thank you so much!

Dear Malini,

I would *never* have recommended amoxicillin, even in a nebulizer.  That drug can be deadly to rabbits, and you should not use it on your rabbit.  Ever.

The "cocktail" I have described consisted of sterile saline, amikacin (antibiotic), acetylcysteine (to loosen mucus), and aminophylline (to open airways).  

Chronic nasal congestion is often not due only to bacterial infection.  There is usually a physical problem--such as a narrowing of the sinuses due to dental intrusion--that predisposes a bunny to bacterial growth in the sinuses. Please see:


The combination of runny nose and eyes is a very strong hint that her problems are dental in origin.  Probably not curable, but controllable with supportive care and appropriate antibiotics as prescribed by your veterinarian.



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Dana Krempels, Ph.D.


I've lived with companion rabbits for more than 35 years, and consider them members of my family. I can answer any questions about the biology and health of rabbits, from the commonplace to the unusual. But please note:

RULE #1:

Find a rabbit vet at for immediate help, and don't risk your bunny's life by spending time asking questions online! If you can't get in touch with your vet, read these Emergency Sick Bunny Instructions.

If you have found a wild baby rabbit, please read these EMERGENCY INSTRUCTIONS FOR WILD BABY RABBITS and then use this link to FIND A LOCAL WILDLIFE REHABILITATOR who can give you the right advice.

RULE #2:
Help me help you! Please make your subject line informative if you have an urgent question. then LET ME KNOW IN THE SUBJECT LINE so I can give your question highest priority over non-urgent questions. If you don't do this, then I can't guarantee timely assistance!

For all the best, most accurate rabbit health, care and behavior information, visit The House Rabbit Society.


I have been rescuing and rehabilitating domestic and wild rabbits for about 30 years. I have written articles for many rabbit rescue publications, as well as for the veterinary journal, Exotic DVM. I own EtherBun, the internet's largest listserve dedicated to health, care, and behavior of domestic rabbits.

Houserabbit Adoption, Rescue, and Education, Inc. (H.A.R.E., Inc.) president National House Rabbit Society (Board member)

Exotic DVM
Warren Peace (Journal of the House Rabbit Society of Miami)
Various newsletters of the House Rabbit Society, nationwide

Ph.D - Biology
B.S. - Biology
B.A. - English

Awards and Honors
Lightspan Academic Excellence Award for web site on rabbit health and biology

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