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Urology/Do Alpha1 blockers cause the side effect of lower abdominal pain?


Hi Dr! I have been diagnosed with the bladder outlet obstruction (BOO) due to the BPH and may have chronic prostatitis. The different urologists have prescribed the Flomax, Alfuzosin and antibiotics but the Flomax and Alfuzosin caused my lower abdominal mild pain. I have to take the Ibuprofen to relieve the pain. I thought the pain was due to the chronic prostatitis because it can cause the lower abdominal pain and distention.  However, I noticed the pain went away if I stopped the Flomax or Alfuzosin, and the pain came back after I resumed the drugs. I begin to realize the mild lower abdominal pain is due to the drug but the prostatitis. Can you confirm whether the Flomax and Alfuzosin can cause the lower abdominal pain? If so, does it mean all the Alpha1-adrenergic blockers have the side effects of the lower abdominal pain? Is there alternative drugs to treat the BOO without the side effect of the lower abdominal pain? Thank you for your answer.


It is not typical for flomax or alfuzosin to cause any abdominal pain, but your experience suggests that in your case it might.  I am also unaware orf any scientific mechanism that would explain abdominal pain caused by these agents.  Nevertheless, if they are bothering you then you probably shouldn't take them, but how they might be causing a problem is a bit of mystery as this problem has not been reported.

Alternative drugs for bladder outlet obstruction would be 5ARI type meds, but these take months to work.  For a quick response and improvement, we're stuck with the alpha blocker type meds you can't take.

Obviously, you'll need to discuss this with your physician.


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Stephen W. Leslie, MD


Questions concerning erectile dysfunction, kidney stones and prostate disorders including prostate cancer. I have a special interest in kidney stone disease prevention.


Full time practicing urologist with 30 years experience. Associate Professor of Surgery and Chief of Urology at Creighton University Medical Center. Editor in Chief of eMedicine Urology internet textbook. Author of only NIH approved book written for patients by a urologist on the subject of kidney stones "The Kidney Stones Handbook". Inventor of the "Parachute" and "Escape" kidney stone baskets and the "Calculus" stone prevention analysis computer program.

American Urological Association, Ohio State Medical Association, Sexual Medicine Society

Men's Health, Journal of Urology, Urology, Healthwatch Magazine, Emergency Medicine Monthly, eMedicine, "The Kidney Stones Handbook", and numerous articles in various newspapers. He is also the editor of the Urology Board Review by McGraw-Hill used by urologists to study for their Board Certification Examinations.

Graduate of New York Medical College with residencies completed at Metropolitan Hospital New York, Albany Medical Center and University of Wisconsin-Madison.

Awards and Honors
Thirlby Award of the American Urological Association. Rated as one the country's Best Urologists by the Independent Consumer's Research Institute

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