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Urology/BPH and antihistamines


I am a retired 65 year old American male living in Malaysia. I have BPH and chronic sinusitis. Every healthcare professional I have seen says to avoid antihistamines if I have BPH, but no one can tell me what antihistamine is safe to take. Can you tell me if there is an antihistamine that I can take to alleviate my sinus problems and still be able to urinate? Thank you for your time.


First, chronic sinusitis can be treated with inhaled steroids and antibiotics.  Most first generation antihistamines (benadryl) have some anti-cholinergic (bladder relaxing) effects which can cause problems with urination.  Second generation antihistamines are usually considered safe.  Such medications include zyrtec, claritin and allegra.  Avoid decongestants as they will all have a worsening effect on the prostate.


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Stephen W. Leslie, MD


Questions concerning erectile dysfunction, kidney stones and prostate disorders including prostate cancer. I have a special interest in kidney stone disease prevention.


Full time practicing urologist with 30 years experience. Associate Professor of Surgery and Chief of Urology at Creighton University Medical Center. Editor in Chief of eMedicine Urology internet textbook. Author of only NIH approved book written for patients by a urologist on the subject of kidney stones "The Kidney Stones Handbook". Inventor of the "Parachute" and "Escape" kidney stone baskets and the "Calculus" stone prevention analysis computer program.

American Urological Association, Ohio State Medical Association, Sexual Medicine Society

Men's Health, Journal of Urology, Urology, Healthwatch Magazine, Emergency Medicine Monthly, eMedicine, "The Kidney Stones Handbook", and numerous articles in various newspapers. He is also the editor of the Urology Board Review by McGraw-Hill used by urologists to study for their Board Certification Examinations.

Graduate of New York Medical College with residencies completed at Metropolitan Hospital New York, Albany Medical Center and University of Wisconsin-Madison.

Awards and Honors
Thirlby Award of the American Urological Association. Rated as one the country's Best Urologists by the Independent Consumer's Research Institute

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