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Urology/When should the prostate biopsy be performed again?


A 50s man has prostate disorder, recurrent prostate infection and lower abdominal/bladder distension and fullness. The PSA has been increasing from 2.2 to 2.5 within two years. An urologist performed the prostate biopsy. The result as expected is negative. So the doctor diagnosed the BPH and prostatitis. Since one year passed, the PSA has increased to 2.6. When should the prostate biopsy be performed again or it is unnecessary in some years such as 3, 5 etc after the first time prostate biopsy?


Assuming there are not definitive nodule or anything else suspicious, the general guideline is to wait until there has been a 25% increase from the last PSA or in this case roughly 3.2 or higher.

But this is only a guideline and the actual decision should be made by the patient's urologist.


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Stephen W. Leslie, MD


Questions concerning erectile dysfunction, kidney stones and prostate disorders including prostate cancer. I have a special interest in kidney stone disease prevention.


Full time practicing urologist with 30 years experience. Associate Professor of Surgery and Chief of Urology at Creighton University Medical Center. Editor in Chief of eMedicine Urology internet textbook. Author of only NIH approved book written for patients by a urologist on the subject of kidney stones "The Kidney Stones Handbook". Inventor of the "Parachute" and "Escape" kidney stone baskets and the "Calculus" stone prevention analysis computer program.

American Urological Association, Ohio State Medical Association, Sexual Medicine Society

Men's Health, Journal of Urology, Urology, Healthwatch Magazine, Emergency Medicine Monthly, eMedicine, "The Kidney Stones Handbook", and numerous articles in various newspapers. He is also the editor of the Urology Board Review by McGraw-Hill used by urologists to study for their Board Certification Examinations.

Graduate of New York Medical College with residencies completed at Metropolitan Hospital New York, Albany Medical Center and University of Wisconsin-Madison.

Awards and Honors
Thirlby Award of the American Urological Association. Rated as one the country's Best Urologists by the Independent Consumer's Research Institute

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