You are here:

Urology/Urethral burning


Hello, my name is keziah, i'm a female. i'm not sure if you can answer my question but over the past 4 years i have been dealing with urethral burning, no other symptoms. My urethra is irritated the most during my period. I have been to plenty of doctors and my urine test and cultures always come back negative. I was finally referred to a urologist and they did an ultrasound on my bladder and kidneys and also a cystoscopy. Both the ultrasound and cystoscopy came back normal. I am at a loss for what it could be. I know it is not all in my head. Do you have any ideas of what else it could possibly be? Thank you in advance!


Nothing is harder to treat than a sensation when all the tests are negative.  So we get back to basics:

A trial of an antibiotic like doxycycline that covers a lot of "weird" infections.  Might help.

Use of "Prelief" which is a calcium supplement that tends to make the urine less irritating.

Low oxalate diet.  In some women, tiny calcium oxalate crystals can form in the lining of the urethra and cause pain/burning with all the tests negative.

Now discuss these possibilities with your physicians to see if any might be worth a try in your particular case.


All Answers

Answers by Expert:

Ask Experts


Stephen W. Leslie, MD


Questions concerning erectile dysfunction, kidney stones and prostate disorders including prostate cancer. I have a special interest in kidney stone disease prevention.


Full time practicing urologist with 30 years experience. Associate Professor of Surgery and Chief of Urology at Creighton University Medical Center. Editor in Chief of eMedicine Urology internet textbook. Author of only NIH approved book written for patients by a urologist on the subject of kidney stones "The Kidney Stones Handbook". Inventor of the "Parachute" and "Escape" kidney stone baskets and the "Calculus" stone prevention analysis computer program.

American Urological Association, Ohio State Medical Association, Sexual Medicine Society

Men's Health, Journal of Urology, Urology, Healthwatch Magazine, Emergency Medicine Monthly, eMedicine, "The Kidney Stones Handbook", and numerous articles in various newspapers. He is also the editor of the Urology Board Review by McGraw-Hill used by urologists to study for their Board Certification Examinations.

Graduate of New York Medical College with residencies completed at Metropolitan Hospital New York, Albany Medical Center and University of Wisconsin-Madison.

Awards and Honors
Thirlby Award of the American Urological Association. Rated as one the country's Best Urologists by the Independent Consumer's Research Institute

©2017 All rights reserved.