You are here:

Urology/High estradiol?


My E2-levels were 0.16nmol/l and normal value should be below 0.13nmol/l. Can high estradiol cause penile shrinkage and is this shrinkage permanent or may the penis recover in size after you get your E2-levels to normal range? Can high estradiol levels cause venous leakage or any damage that's not reversable?

John, endocrinology is not my expertise but I shall try to help you.  If not satisfied, I suggest you forward your question to an endocrinologist.  The normal estradiol (E2) level in a male is 10-60 pg/ml.  This converts to 0.06-0.35 nmol/L.  Based on these normal male levels, you have a perfectly normal level of estradiol.  The testicles produce testosterone as well as smaller amounts of female hormones.    In a man, the balance of male hormone to female hormone is really what determines how a male functions sexually as well as his genital appearance.  Higher than normal levels of estradiol and/or lower than normal levels of testosterone may cause subtle changes in a man's genitalia as well as possibly hinder his sexual performance.  Changes in the appearance of a male's genitalia usually can be reverted back to normal with hormone rebalancing.  To the best of my knowledge, higher levels of estradiol will not cause venous leakage.  

To re-iterate, however, you E2 level is normal according to all parameters I could find.  Good luck.


All Answers

Answers by Expert:

Ask Experts


Arthur Goldstein, M.D.


Problems or questions related to the field of urology; ie urinary stone disease, urinary cancers (kidney, bladder, prostate, testis, etc.), urinary infections, etc. I no longer answer questions related to erection problems or male sexual dysfunction.


I am retired from the active practice of urology. My 34 years was totally in the clinical field and involved the entire gamut of genitourinary problems, with special interest in endourology.

American Medical Association, American Urological Association, American College of Surgeons

College degree - BS Medical degree - MD Master of Science - MS

©2017 All rights reserved.