My E2-levels were 0.16nmol/l and normal value should be below 0.13nmol/l. Can high estradiol cause penile shrinkage and is this shrinkage permanent or may the penis recover in size after you get your E2-levels to normal range? Can high estradiol levels cause venous leakage or any damage that's not reversable?
John, endocrinology is not my expertise but I shall try to help you. If not satisfied, I suggest you forward your question to an endocrinologist. The normal estradiol (E2) level in a male is 10-60 pg/ml. This converts to 0.06-0.35 nmol/L. Based on these normal male levels, you have a perfectly normal level of estradiol. The testicles produce testosterone as well as smaller amounts of female hormones. In a man, the balance of male hormone to female hormone is really what determines how a male functions sexually as well as his genital appearance. Higher than normal levels of estradiol and/or lower than normal levels of testosterone may cause subtle changes in a man's genitalia as well as possibly hinder his sexual performance. Changes in the appearance of a male's genitalia usually can be reverted back to normal with hormone rebalancing. To the best of my knowledge, higher levels of estradiol will not cause venous leakage.
To re-iterate, however, you E2 level is normal according to all parameters I could find. Good luck.