Is it possible for medications like Praxilene (naftidrofuryl) to have a useful effect in enhancing poor blood circulation of the penis? (i.e. in men suffering ED due to arterial insufficiency)

And what could be possible causes of penile arterial insufficiency in young males (20-30 years old) who do not suffer diabetes or hypertension and have normal blood cholesterol levels? Could problems with the prostate be causing this?

In theory, a vasodilator should help with ED, especially if due to insufficient blood flow.  However, in most cases, systemic vasodilators used for blood pressure or vascular disease are insufficient to correct ED.  If you used a high enough dose to affect erection function, there would be such a great general vasodilator effect in the whole body that the blood pressure would drop to dangerously low levels.  The key to ED treatment is to get a vasodilator effect on the penis and not on anything else.  That's why viagra type meds work and vasodilators like Praxilene don't.

There are many causes of ED of which arteriol insufficiency is only one.  The most common cause of arterial insufficiency in the 20-30 year old age group would be trauma or injury.

Other causes for ED would include low hormone levels, nerve issues, venous leak, intrinsic disease of the erectile tissue, diabetes, medication effects and psychogenic factors.

Problems with the prostate such as prostatitis can cause ED but this would be a relatively uncommon side effect of prostatitis.

Now go see your physician to get this problem treated.


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Stephen W. Leslie, MD


Questions concerning erectile dysfunction, kidney stones and prostate disorders including prostate cancer. I have a special interest in kidney stone disease prevention.


Full time practicing urologist with 30 years experience. Associate Professor of Surgery and Chief of Urology at Creighton University Medical Center. Editor in Chief of eMedicine Urology internet textbook. Author of only NIH approved book written for patients by a urologist on the subject of kidney stones "The Kidney Stones Handbook". Inventor of the "Parachute" and "Escape" kidney stone baskets and the "Calculus" stone prevention analysis computer program.

American Urological Association, Ohio State Medical Association, Sexual Medicine Society

Men's Health, Journal of Urology, Urology, Healthwatch Magazine, Emergency Medicine Monthly, eMedicine, "The Kidney Stones Handbook", and numerous articles in various newspapers. He is also the editor of the Urology Board Review by McGraw-Hill used by urologists to study for their Board Certification Examinations.

Graduate of New York Medical College with residencies completed at Metropolitan Hospital New York, Albany Medical Center and University of Wisconsin-Madison.

Awards and Honors
Thirlby Award of the American Urological Association. Rated as one the country's Best Urologists by the Independent Consumer's Research Institute

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