hello doctor, i'm 32 years old healthy male. I had some acidity related problem so my dr prescribed me pantaprazole with levosulpiride. After taking it for two days i'm experiencing low libido and ed. I read that d2 receptor blocker like levosulpiride can cause ED due to high prolactin. I'm not sure but may be it can cause permanent erectile dysfunction or low libido? plz guide.


I am not personally familiar with this drug, however in researching it I found that it can indeed increase prolactin levels which would decrease testosterone.  This is not likely to be permanent and it does not cause ED.  A lower dose of the drug can be tried or it can be stopped and an alternative drug ordered for you.


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Stephen W. Leslie, MD


Questions concerning erectile dysfunction, kidney stones and prostate disorders including prostate cancer. I have a special interest in kidney stone disease prevention.


Full time practicing urologist with 30 years experience. Associate Professor of Surgery and Chief of Urology at Creighton University Medical Center. Editor in Chief of eMedicine Urology internet textbook. Author of only NIH approved book written for patients by a urologist on the subject of kidney stones "The Kidney Stones Handbook". Inventor of the "Parachute" and "Escape" kidney stone baskets and the "Calculus" stone prevention analysis computer program.

American Urological Association, Ohio State Medical Association, Sexual Medicine Society

Men's Health, Journal of Urology, Urology, Healthwatch Magazine, Emergency Medicine Monthly, eMedicine, "The Kidney Stones Handbook", and numerous articles in various newspapers. He is also the editor of the Urology Board Review by McGraw-Hill used by urologists to study for their Board Certification Examinations.

Graduate of New York Medical College with residencies completed at Metropolitan Hospital New York, Albany Medical Center and University of Wisconsin-Madison.

Awards and Honors
Thirlby Award of the American Urological Association. Rated as one the country's Best Urologists by the Independent Consumer's Research Institute

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